Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Pax6  paired box 6   (Synonyms: 1500038E17Rik, AEY11, Dey, Dickie's small eye, Gsfaey11, Pax-6)
Results	Reference
1*	J:76822 Anderson TR, Hedlund E, Carpenter EM, Differential Pax6 promoter activity and transcript expression during forebrain development. Mech Dev. 2002 Jun;114(1-2):171-5
1	J:86369 Andrews GL, Mastick GS, R-cadherin is a Pax6-regulated, growth-promoting cue for pioneer axons. J Neurosci. 2003 Oct 29;23(30):9873-80
1*	J:80177 Aoto K, Nishimura T, Eto K, Motoyama J, Mouse GLI3 Regulates Fgf8 Expression and Apoptosis in the Developing Neural Tube, Face, and Limb Bud. Dev Biol. 2002 Nov 15;251(2):320-32
1	J:127387 Armentano M, Chou SJ, Tomassy GS, Leingartner A, O'Leary DD, Studer M, COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas. Nat Neurosci. 2007 Oct;10(10):1277-86
1	J:110211 Baek JH, Hatakeyama J, Sakamoto S, Ohtsuka T, Kageyama R, Persistent and high levels of Hes1 expression regulate boundary formation in the developing central nervous system. Development. 2006 Jul;133(13):2467-76
1*	J:52338 Bassett JH, Rashbass P, Harding B, Forbes SA, Pannett AA, Thakker RV, Studies of the murine homolog of the multiple endocrine neoplasia type 1 (MEN1) gene, men1. J Bone Miner Res. 1999 Jan;14(1):3-10
1*	J:71879 Bernier G, Vukovich W, Neidhardt L, Herrmann BG, Gruss P, Isolation and characterization of a downstream target of Pax6 in the mammalian retinal primordium. Development. 2001 Oct;128(20):3987-94
1	J:198381 Carbe C, Garg A, Cai Z, Li H, Powers A, Zhang X, An allelic series at the paired box gene 6 (Pax6) locus reveals the functional specificity of Pax genes. J Biol Chem. 2013 Apr 26;288(17):12130-41
1	J:182769 Carbe C, Hertzler-Schaefer K, Zhang X, The functional role of the Meis/Prep-binding elements in Pax6 locus during pancreas and eye development. Dev Biol. 2012 Mar 1;363(1):320-9
1	J:54652 Davenne M, Maconochie MK, Neun R, Pattyn A, Chambon P, Krumlauf R, Rijli FM, Hoxa2 and Hoxb2 control dorsoventral patterns of neuronal development in the rostral hindbrain. Neuron. 1999 Apr;22(4):677-91
1*	J:206224 Dixit R, Tachibana N, Touahri Y, Zinyk D, Logan C, Schuurmans C, Gene expression is dynamically regulated in retinal progenitor cells prior to and during overt cellular differentiation. Gene Expr Patterns. 2014 Jan;14(1):42-54
1*	J:48135 Fernandez AS, Pieau C, Reperant J, Boncinelli E, Wassef M, Expression of the Emx-1 and Dlx-1 homeobox genes define three molecularly distinct domains in the telencephalon of mouse, chick, turtle and frog embryos: implications for the evolution of telencephalic subdivisions in amniotes. Development. 1998 Jun;125(11):2099-111
1	J:134674 Fogel JL, Chiang C, Huang X, Agarwala S, Ventral specification and perturbed boundary formation in the mouse midbrain in the absence of Hedgehog signaling. Dev Dyn. 2008 May;237(5):1359-72
1*	J:91257 Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk DI, Tsung EF, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, Greenberg ME, McMahon AP, Rowitch DH, Stiles CD, Ma Q, Mouse Brain Organization Revealed Through Direct Genome-Scale TF Expression Analysis. Science. 2004 Dec 24;306(5705):2255-2257
1*	J:41401 Grindley JC, Hargett LK, Hill RE, Ross A, Hogan BL, Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. Mech Dev. 1997 Jun;64(1-2):111-26
1*	J:96452 Gurniak CB, Perlas E, Witke W, The actin depolymerizing factor n-cofilin is essential for neural tube morphogenesis and neural crest cell migration. Dev Biol. 2005 Feb 1;278(1):231-41
1	J:119561 Hirata T, Nakazawa M, Muraoka O, Nakayama R, Suda Y, Hibi M, Zinc-finger genes Fez and Fez-like function in the establishment of diencephalon subdivisions. Development. 2006 Oct;133(20):3993-4004
1*	J:70346 Kim AS, Anderson SA, Rubenstein JL, Lowenstein DH, Pleasure SJ, Pax-6 regulates expression of SFRP-2 and Wnt-7b in the developing CNS. J Neurosci. 2001 Mar 1;21(5):RC132
1	J:109412 Kim J, Lauderdale JD, Analysis of Pax6 expression using a BAC transgene reveals the presence of a paired-less isoform of Pax6 in the eye and olfactory bulb. Dev Biol. 2006 Apr 15;292(2):486-505
1	J:98539 Kimura J, Suda Y, Kurokawa D, Hossain ZM, Nakamura M, Takahashi M, Hara A, Aizawa S, Emx2 and Pax6 function in cooperation with Otx2 and Otx1 to develop caudal forebrain primordium that includes future archipallium. J Neurosci. 2005 May 25;25(21):5097-108
1*	J:91011 Kurokawa D, Kiyonari H, Nakayama R, Kimura-Yoshida C, Matsuo I, Aizawa S, Regulation of Otx2 expression and its functions in mouse forebrain and midbrain. Development. 2004 Jul;131(14):3319-31
1	J:84901 Kuschel S, Ruther U, Theil T, A disrupted balance between Bmp/Wnt and Fgf signaling underlies the ventralization of the Gli3 mutant telencephalon. Dev Biol. 2003 Aug 15;260(2):484-95
1	J:196292 Marinic M, Aktas T, Ruf S, Spitz F, An integrated holo-enhancer unit defines tissue and gene specificity of the Fgf8 regulatory landscape. Dev Cell. 2013 Mar 11;24(5):530-42
1	J:62027 Martinez Barbera JP, Clements M, Thomas P, Rodriguez T, Meloy D, Kioussis D, Beddington RS, The homeobox gene Hex is required in definitive endodermal tissues for normal forebrain, liver and thyroid formation. Development. 2000 Jun;127(11):2433-45
1	J:84388 Mastick GS, Andrews GL, Pax6 regulates the identity of embryonic diencephalic neurons. Mol Cell Neurosci. 2001 Jan;17(1):190-207
1*	J:41030 Mastick GS, Davis NM, Andrew GL, Easter SS Jr, Pax-6 functions in boundary formation and axon guidance in the embryonic mouse forebrain. Development. 1997 May;124(10):1985-97
1	J:294016 Medina-Martinez O, Haller M, Rosenfeld JA, O'Neill MA, Lamb DJ, Jamrich M, The transcription factor Maz is essential for normal eye development. Dis Model Mech. 2020 Aug 18;13(8):dmm044412
1*	J:71951 Ohnemus S, Bobola N, Kanzler B, Mallo M, Different levels of Hoxa2 are required for particular developmental processes. Mech Dev. 2001 Oct;108(1-2):135-47
1*	J:149237 Perez-Balaguer A, Puelles E, Wurst W, Martinez S, Shh dependent and independent maintenance of basal midbrain. Mech Dev. 2009 May-Jun;126(5-6):301-13
1	J:89367 Puelles E, Annino A, Tuorto F, Usiello A, Acampora D, Czerny T, Brodski C, Ang SL, Wurst W, Simeone A, Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain. Development. 2004 May;131(9):2037-48
1*	J:26182 Schubert FR, Fainsod A, Gruenbaum Y, Gruss P, Expression of the novel murine homeobox gene Sax-1 in the developing nervous system. Mech Dev. 1995 May;51(1):99-114
1*	J:55154 Schwarz M, Alvarez-Bolado G, Dressler G, Urbanek P, Busslinger M, Gruss P, Pax2/5 and Pax6 subdivide the early neural tube into three domains. Mech Dev. 1999 Apr;82(1-2):29-39
1*	J:209112 Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H, The AERO system: a 3D-like approach for recording gene expression patterns in the whole mouse embryo. PLoS One. 2013;8(10):e75754
1*	J:77801 Soo K, O'Rourke MP, Khoo PL, Steiner KA, Wong N, Behringer RR, Tam PP, Twist function is required for the morphogenesis of the cephalic neural tube and the differentiation of the cranial neural crest cells in the mouse embryo. Dev Biol. 2002 Jul 15;247(2):251-70
1	J:95319 Spoelgen R, Hammes A, Anzenberger U, Zechner D, Andersen OM, Jerchow B, Willnow TE, LRP2/megalin is required for patterning of the ventral telencephalon. Development. 2005 Jan;132(2):405-14
1*	J:154376 Stottmann RW, Tran PV, Turbe-Doan A, Beier DR, Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Dev Biol. 2009 Nov 1;335(1):166-78
1*	J:70745 Suda Y, Hossain ZM, Kobayashi C, Hatano O, Yoshida M, Matsuo I, Aizawa S, Emx2 directs the development of diencephalon in cooperation with Otx2. Development. 2001 Jul;128(13):2433-50
1	J:237489 Ware M, Hamdi-Roze H, Le Friec J, David V, Dupe V, Regulation of downstream neuronal genes by proneural transcription factors during initial neurogenesis in the vertebrate brain. Neural Dev. 2016 Dec 07;11(1):22
1*	J:40189 Warren N, Price DJ, Roles of Pax-6 in murine diencephalic development. Development. 1997 APR;124(8):1573-1582
1*	J:156017 Yokoyama S, Ito Y, Ueno-Kudoh H, Shimizu H, Uchibe K, Albini S, Mitsuoka K, Miyaki S, Kiso M, Nagai A, Hikata T, Osada T, Fukuda N, Yamashita S, Harada D, Mezzano V, Kasai M, Puri PL, Hayashizaki Y, Okado H, Hashimoto M, Asahara H, A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Dev Cell. 2009 Dec;17(6):836-48
1	J:66894 Zhang L, Mathers PH, Jamrich M, Function of Rx, but not Pax6, is essential for the formation of retinal progenitor cells in mice. Genesis. 2000 Nov-Dec;28(3-4):135-42
1	J:78468 Zhang X, Friedman A, Heaney S, Purcell P, Maas RL, Meis homeoproteins directly regulate Pax6 during vertebrate lens morphogenesis. Genes Dev. 2002 Aug 15;16(16):2097-107
1*	J:156737 Zhao L, Saitsu H, Sun X, Shiota K, Ishibashi M, Sonic hedgehog is involved in formation of the ventral optic cup by limiting Bmp4 expression to the dorsal domain. Mech Dev. 2010 January - February;127(1-2):62-72
1*	J:143210 Zhou CJ, Molotkov A, Song L, Li Y, Pleasure DE, Pleasure SJ, Wang YZ, Ocular coloboma and dorsoventral neuroretinal patterning defects in Lrp6 mutant eyes. Dev Dyn. 2008 Dec;237(12):3681-9